MOLECULAR DOCKING AND SCREENING OF DRUGS FOR 6LU7 PROTEASE INHIBITOR AS A POTENTIAL TARGET FOR COVID-19
نویسندگان
چکیده
Objective: The aim of present investigation is docking various existing antiviral, anti-tubercular and anti-malarial drugs on 6LU7 receptor SARS-CoV-2 in the treatment COVID-19. Methods: In this study, structure coronavirus binding protein ligands for were collected from data bank pub chem. Molecular was carried out using Schrodinger 9.0 software. molecular 19 different categories like investigated analyzing to receptors Results: result showed a high affinity zanamivir, montelukast, ramdesvir, ritonavir, cobicistat favipravir novel coronavirus. Thus combination these may be useful preventing further infection can used as potential target vitro vivo studies SARS-CoV-2. Conclusion: Treatment COVID-19 has been challenge due non-availability effective drug therapy. we reported targeting Mpro/3Clpro protein, which prominent effects inhibitors Mpro.
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2022
ISSN: ['0975-7058']
DOI: https://doi.org/10.22159/ijap.2022v14i1.43132